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Therapy with Nasal Insufflation...the more efficient NHF Therapy

From the clinic

intensiv or clinical

as well as in homecare

adult COPD-/ILD- or OSA-patients,

neonatals, IRDS-/BPD-or Bronchiolitis- patients,

prematures, neonatals and infant OSA-patients

the TNI-systems guarantee

an exact regulated flow ratea stable FiO2

an effective humidity management


TNI® - efficient therapy follows patients

Our product range:

Method and Effects

During the therapy, a constant warm and humidified air flow, if required combined with oxygen, is applied into the nose of the patient by means of thin nasal prongs (applicator). This always leads to an improved ventilation. The Therapy with Nasal Insufflation has a high level of therapy acceptance and excellent therapeutic success.

A number of attestations and clinical findings show that the Therapy with Nasal Insufflation actually

  • supports insufficient breathing and shows a clinical benefit
  • which leads to improved elimination of CO2,
  • reduces the functional dead space,
  • supports and relieves the respiratory pump


The findings especially recommend the Therapy with Nasal Insufflation as a therapy option for a further reduction of a mechanical respiratory support or for patients who do not accept the usual mask ventilation.

Publications / Studies

Below, you will find a selection of current publications on the Nasal High Flow therapy.




Öffnet einen externen Link in einem neuen FensterJens Bräunlich, Dominic Dellweg, Andreas Bastian, Stephan Budweiser, Winfried Randerath, Dora Triché, Martin Bachmann, Christian Kähler, Abdel Hakim Bayarassou, Irmhild Mäder, Jens Geiseler, Norbert Köhler, David Petroff, Hubert Wirtz
Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD
International Journal of Chronic Obstructive Pulmonary Disease 2019:14 1411–1421
Published: 5 July 2019
Öffnet einen externen Link in einem neuen FensterHelene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki and Christian M. Kaehler, 2017
Efficacy and safety of nasal high-flow oxygen in COPD patients
BMC Pulmonary MedicineBMC series – open, inclusive and trusted 201717:143

17 November 2017
Bräunlich, J., Köhler, M., Wirtz, H., 2016.
Nasal highflow improves ventilation in patients with COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 11, 1077–1085. doi:10.2147/COPD.S104616

Bräunlich, J., Nilius, G., 2016. Nasaler Highflow (NHF): Eine neue Therapiealternative zur Behandlung der respiratorischen Insuffizienz. Pneumologie 70, 49–54. doi:10.1055/s-0041-110286

Bräunlich, J., Wirtz, H., 2015. Nasaler Highflow – Bessere Alternative der Sauerstoffapplikation bei schwerer Hypoxie? Dtsch Med Wochenschr 140, 1823–1826. doi:10.1055/s-0041-107889
Startet einen Datei-DownloadBräunlich, J., Seyfarth, H.-J., Wirtz, H., 2015
Nasal High-flow versus
non-invasive ventilation in stable hypercapnic COPD:

a preliminary report. Multidiscip. Respir. Med. 10, 27. doi:10.1186/s40248-015-0019-y

Bräunlich, J., Beyer, D., Mai, D., Hammerschmidt, S., Seyfarth, H.J., Wirtz, H., 2013. Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients. Respiration 85. doi:10.1159/000342027

Startet einen Datei-DownloadMcGinley, B.M., Patil, S.P., Kirkness, J.P., Smith, P.L., Schwartz, A.R., Schneider, H., 2007:
A Nasal Cannula Can Be Used to Treat Obstructive Sleep Apnea

Am. J. Respir. Crit. Care Med. 176, 194–200. doi:10.1164/rccm.200609-1336OC

Startet einen Datei-DownloadNilius, G., Franke, K.-J., Domanski, U., Rühle, K.-H., Kirkness, J.P., Schneider, H., 2013. Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. Adv. Exp. Med. Biol. 755, 27–34. doi:10.1007/978-94-007-4546-9_49180

Nilius, G., Wessendorf, T., Maurer, J., Stoohs, R., Patil, S.P., Schubert, N., Schneider, H., 2009. Predictors for Treating Obstructive Sleep Apnea With an Open Nasal Cannula System (Transnasal Insufflation). ResearchGate 137, 521–8. doi:10.1378/chest.09-0357

Plattner, L., Vogelsinger, H., Janschek, E., Kähler, C.M., 2013. Highflow-Sauerstofftherapie – Auswirkung auf die Blutgase bei schwerer COPD. Pneumologie 67, P35. doi:10.1055/s-0033-1345073

Vogelsinger, H., Halank, M., Wilkens, H., Geiser, T., Braun, S., Plattner, L., Janschek, E., Ott, S., Stucki, A., Kaehler, C.M., 2013. Highflow-Sauerstoffttherapie bei hyperkapnischen COPD-Patienten: optimiertes Sauerstoffangebot – Daten aus der STIT-2-Studie. Pneumologie 67, P40. doi:10.1055/s-0033-1345078


McGinley, B., Halbower, A., Schwartz, A.R., Smith, P.L., Patil, S.P., Schneider, H., 2009. Effect of a high-flow open nasal cannula system on obstructive sleep apnea in children. Pediatrics 124, 179–188. doi:10.1542/peds.2008-2824



Posters and Congress contributions

Startet einen Datei-DownloadDer Nasale Highflow (NHF) reduziert das CO2 durch Auswaschung in einem Schafslungenmodell (2016)

Startet einen Datei-DownloadNasaler Highflow: Oxygenierungsverhalten unter verschiedenen Flowstufen (2016)

Startet einen Datei-DownloadAuswirkungen des Nasalen Highflow (NHF) auf die Hämodynamik (2015)

Startet einen Datei-DownloadNasaler High Flow (NHF)-Quantifizierung des CO2 Auswascheffektes in einem Lungenmodell (2015)

Startet einen Datei-DownloadNasaler High Flow (NHF) - Konkurrenz für die Sauerstofftherapie? (2015)

Startet einen Datei-DownloadLangzeiteffekte eines nasalen High Flow (NHF) bei Partienten mit COPD (2013)

Startet einen Datei-DownloadNasal High Flow (NHF): Ist es ein wash-out Effekt? (2013)

Startet einen Datei-DownloadComparison of two different O2-delivery systems during exercise in patients with chronic hypoxia (2011)

Startet einen Datei-DownloadSTIT-1: Evaluation of safety and efficacy of shorttime TNI® treatment in patients with COPD (2010)

Startet einen Datei-DownloadEffects of high-flow transnasal insufflation compared with CPAP and spontaneous breathing on pressure amplitude and mean pressure in patients with IPF and COPD (2010)

Startet einen Datei-DownloadEinfluss der transnasalen Insufflation TNI® auf Atemdruckamblitude & Atemmitteldruck im Vergleich zu Spontanatmung und CPAP (2010)

Startet einen Datei-DownloadEffect of an Open Nasal Cannula System (TNI®) in hypercapnic respiratory failure in COPD patients (2009)

Startet einen Datei-DownloadEinfluss der transnasalen Insufflation (TNI®) auf Atemdruckamplitude und Atemmitteldruck im Vergleich zu Spontanatmung und CPAP beim Lungengesunden (2009)

Startet einen Datei-DownloadTreatment of Sleep-Disordered Breathing in Chronic Obstructive Pulmonary Disease with Nocturnal Nasal Insufflation (2007)

Startet einen Datei-DownloadSommnologie 2007:
072: Multicenterstudie zur Wirksamkeit der transnasalen Insufflation (TNI®) bei leichter bis mittelgradiger pharyngealer Obstruction und Schlafapnoe

Öffnet einen externen Link in einem neuen FensterCleven, J., Vogelsinger, H., Ott, S., Geiser, T., Halank, M., Kähler, C.M., 2012. Effekt transnasaler “High-Flow-Sauerstoff-Insufflation” bei Patienten mit schwerer COPD. Pneumologie 66, P13. doi:10.1055/s-0032-130

Further recommendations:
High-Flow Oxygen through Nasal Cannula
in Acute Hypoxemic Respiratory Failure (Jean-Pierre Frat) 2015
Nasal High-Flow versus Venturi Mask Oxygen Therapy after Extubation (S.M. Maggiore) 2014
Clinical evidence on high flow oxygen therapy and active humidification in adults (C. Gotera) 2013

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+49 931 20 79 29 02
» info@tni-medical.de


+49 931 20 79 29 02
» service@tni-medical.de

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